Tankéré F, Camproux A, Barry B, Guedon C, Depondt J, Gehanno P. Laryngoscope. J Oral Pathol Med. This site needs JavaScript to work properly. Front Oncol. [Clinicopathologic features and prognostic factors of cervical lymph node metastasis in oral squamous cell carcinoma]. Free Online Library: Clinicopathological prognostic factors of oral squamous cell carcinoma: An experience of a tertiary care hospital. Disease staging, extracapsular dissemination, resection margin free of disease, and tumor thickness are factors with high influence on the prognosis. Epub 2021 Feb 22. Patient survival depended on tumor size and the extent of lymph node metastasis: survival was 80.1% (n=23) for T1 tumors and only 16.2% (n=28) for T4 tumors, 68.7% (n=55) at the N0 stage and 42.8% at >N0 (n=44, chi(2) test P=0.01, Fischer's exact test P=0.014). Squamous cell carcinoma is managed by surgery, radiation, and chemotherapy From relative risk factors of … Silencing of LINC00284 inhibits cell proliferation and migration in oral squamous cell carcinoma by the miR-211-3p/MAFG axis and FUS/KAZN axis. Accessibility Arora A, Husain N, Bansal A, Neyaz A, Jaiswal R, Jain K, Chaturvedi A, Anand N, Malhotra K, Shukla S. Am J Surg Pathol. This may dictate the course of the condition -, Head Neck. Cancer Biol Ther. esearchers have been looking for factors that can influence the prognosis of oral cancer, because its outcome is highly uncertain. eCollection 2021. Kim MJ, Lim KY, Kim JW, Nam IW, Lee JH, Myoung H. Cancer Lett. 1994 Aug;125(8):1042-5 Clonal analysis as a prognostic factor in multiple oral squamous cell carcinoma. Multivariate analysis of prognostic factors The multivariate analysis of prognostic factors of OSCC is summarized in Table 3. 8600 Rockville Pike Prognostic value of lymph node involvement in oral cancers: a study of 137 cases. Mode of invasion, presence of lymph node metastasis, extra-capsular spread, surgical margins and invasive tumor front grade are clinical and histologic parameters, which are strongly associated with survival rate. Elective Submandibular Gland Resection in Patients with Squamous Cell Carcinomas of the Tongue. Comprehensive elucidation of OSCC’s molecular mechanism is imperative for early detection and treatment, improving patient survival. Introduction. Prognostic value of the immunohistochemical detection of cancer-associated fibroblasts in oral cancer: A systematic review and meta-analysis. The Cox proportional hazards model was used to estimate the independent prognostic factors for OS. PD-L1 Expression in Tumor Cells Is an Independent Unfavorable Prognostic Factor in Oral Squamous Cell Carcinoma Juan C. de Vicente, Tania Rodríguez-Santamarta, Juan P. Rodrigo, Verónica Blanco-Lorenzo, Eva Allonca and Juana M. García-Pedrero DOI: 10.1158/1055-9965.EPI-18-0779 Published March 2019 The identified prognostic factors imply a relatively comprehensive understanding of factors related to survival rate in OSCC patients, and provide an additional tool for selecting patients who need more aggressive treatment design. Prognostic value of serum liver enzymes in oral and oropharynx squamous cell carcinomas. Methods. Outcome and fewer indications for adjuvant therapy for patients with oral squamous cell carcinomas under standardized tumor board conditions. This site needs JavaScript to work properly. 2017 Apr;39(4):694-701. doi: 10.1002/hed.24667. The systemic inflammatory response and nutritional status of patients with malignant tumors are related to postoperative results. This improved to 0.69 and 0.73 with the addition of pattern of invasion.Conclusions Pattern of invasion is an independent prognostic factor in low-stage oral squamous cell carcinoma. Tumor size and lymph node metastases are decisive. OSCC is an aggressive tumor and its prognosis has exhibited little improvement in the last three decades. pEGFR-Tyr 845 expression as prognostic factors in oral squamous cell carcinoma A tissue … e3 Med Oral Patol Oral Cir Bucal-AHEAD OF PRINT - ARTICLE IN PRESS Survival in patients with oral squamous cell carcinoma Multivariate analysis revealed that, among the variables studied, age (p = 0.044), clinical stage (p < 0.001), and treatment (p < 0.001) were … Significant loss of DLC1 expression was observed in oral squamous cell carcinomas as compared with dysplasia (P <0.001, odds ratio=3.8, 95% CI=2.0–7.3), suggesting it … A web-based search for all types of articles published was initiated using MEDLINE/PubMed. Prognostic Factors in Oral Cavity and Oropharyngeal Squamous Cell Carcinoma The Impact of Tumor-Associated Macrophages Benjamin Marcus, M.D. 2017 Jul;41(7):950-960. doi: 10.1097/PAS.0000000000000843. Epub 2017 Sep 5. FOIA The aim of the current review is to present factors (histologic, clinical, genetic and molecular biomarkers) correlated with survival rate in OSCC patients. 1 Douglas Arenberg, M.D. Objectives/hypothesis: Historically, histologic grade has not been considered a useful prognostic factor in head and neck squamous cell carcinoma (SCC). The aim of the present study was to analyze different prognostic factors to calculate the overall survival in oral squamous cell carcinoma (OSCC). Author information: (1)Department of Biomedical and Neuromotor Sciences, Section of Oral Sciences, University of Bologna, Italy. 2015 Apr;23(2):102-10. doi: 10.1177/1066896914565022. Head Neck. Academy Of Medical Sciences of I.R. Epub 2015 Oct 27. Privacy, Help Gröbe A, Rybak L, Schön G, Smeets R, Tribius S, Schafhausen P, Clauditz TS, Hanken H, Heiland M. J Cancer Res Clin Oncol. tumors had a worse prognosis and were bad responders to chemotherapy. Aim: To evaluate variables that can impact the survival rate of patients with squamous-cell carcinoma of the oral cavity. 2021 Feb 4;12(2):152. doi: 10.1038/s41419-021-03434-z. Javadi S, Khademi B, Mohamadianpanah M, Shishegar M, Babaei A. Iran J Otorhinolaryngol. Keywords: oral cancer; hallmarks of cancer; prognostic factors 1. 2019 Nov 18;11(11):1813. doi: 10.3390/cancers11111813. -, Oral Oncol. Keywords: laryngeal squamous cell carcinoma, head and neck squamous cell carcinoma, extranodal extension, prognosis . Evaluation of the Accuracy of Liquid-Based Oral Brush Cytology in Screening for Oral Squamous Cell Carcinoma. We examined the usefulness of the prognostic nutritional index (PNI) as a prognostic tool in patients with oral squamous cell carcinoma who underwent radical surgery. 2019 Jan;48(1):36-42. doi: 10.1111/jop.12803. Google Scholar Li M, Liu H, Zhao Q, Han S, Zhou L, Liu W, Li W, Gao F. Cell Death Dis. Gissi DB(1), Tarsitano A(2), Leonardi E(3), Gabusi A(4), Neri F(5), Marchetti C(2), Montebugnoli L(4), Foschini MP(3), Morandi L(3). 2006 Mar;28(3):256-69 2021 Mar 8;11:630906. doi: 10.3389/fonc.2021.630906. Electronic address: davide.gissi@unibo.it. Focusing on selected proteins, wide range of molecular markers and gene alterations involving in cell cycle regulation, apoptosis, cell migration, cell adhesion and tumor microenvironment have been documented. Prognostic factors of survival rate in oral squamous cell carcinoma: clinical, histologic, genetic and molecular concepts Oral squamous cell carcinoma (OSCC) represents 95% of … Zhu Z, Zhou J, Xiong X, Liu D, Zheng Y, Ding X, Du Y, Gu N, Wu Y, Song X. J Oral Pathol Med. Mechanism of tumour microenvironment in the progression and development of oral cancer. Accounting for the majority of oral cancers, oral squamous cell carcinoma (OSCC) has high incidence and mortality rates, which imposes the need for continuous research on the best therapeutic options ().OSCC treatment is directly associated with tumour stage. Material and Methods: Data analysis of 45 patients from January, 2001 to January, 2006. [Retrospective analysis of the prognostic significance of depth of invasion of advanced oral and oropharyngeal squamous cell carcinomas with lymph node metastases]. Angadi PV, Patil PV, Hallikeri K, Mallapur MD, Hallikerimath S, Kale AD. Clipboard, Search History, and several other advanced features are temporarily unavailable. ENE+ was associated with worse outcomes compared to pN - or ENE- status. FOIA The search was restricted to articles focusing on relevant clinical, histologic, genetic and molecular factors of survival rate in OSCC and presenting new concepts in this field. Methods: Tissue microarrays of 125 resected OSCC were stained with two different commercially available PD-L1 antibodies (clones E1L3N and 22C3), alongside PD-1 immunostaining. Impact of Multidisciplinary Team Management on the Survival Rate of Head and Neck Cancer Patients: A Cohort Study Meta-analysis. Nevertheless, the prognosis of Squamous Cell Carcinoma of Oral Cavity depends upon many factors including the stage of the tumor and health status of the affected individual. Privacy, Help Chin J Stomatol 2016; 51(3): 133 – 136. Epub 2016 Dec 22. 2000 Dec;110(12):2061-5. doi: 10.1097/00005537-200012000-00016. Yang, S, Wang, DC, Wang, X. National Library of Medicine Probably, the pathogenesis of oral SCC in young people involves multiple factors, as genetic and others new behavioral factors [ 32, 33 ]. 1 Mozaffarul Islam, Ph.D. 1 Supriti Paul, M.D. 2017 May;45(5):722-730. doi: 10.1016/j.jcms.2017.01.033. Shang C, Feng L, Gu Y, Hong H, Hong L, Hou J. Introduction Clinical and Histopathologic Independent Prognostic Factors in Oral Squamous Cell Carcinoma: A Retrospective Study of 334 Cases Introduction Head and neck cancer, including oral squamous cell carcinoma (OSCC), is the sixth leading cancer worldwide, with an estimated 300,400 cases and 145,400 OSCC-related deaths occurring in 2012 [1]. These results confirm the central role of EGF-R activation status as a prognostic biomarker in OSCC. 2 Julia Lee, M.S. ENE is an independent prognostic factor in LSCC, and could be an indicator of the need for adjuvant treatment. Please enable it to take advantage of the complete set of features! Dourado MR, Guerra ENS, Salo T, Lambert DW, Coletta RD. oral squamous cell carcinoma. Stage and mRNA expression of survivin in lymph node as prognostic indicators in patients with oral squamous cell carcinoma. Would you like email updates of new search results? Samples retrospectively collected from 99 patients with primary OSCC were analyzed with regard to tumor node metastasis stage, grading, and 5-year survival time and summarized at an SPSS 11.0 databank. Wenzel S, Sagowski C, Kehrl W, Metternich FU. Samples retrospectively collected from 99 patients with primary OSCC were analyzed with regard to tumor node metastasis stage, grading, and 5-year survival time and summarized at an SPSS 11.0 databank. Predictive markers for delayed lymph node metastases and survival in early-stage oral squamous cell carcinoma. -, Cancer Res. Overall incidence and mortality attributed to oral squamous cell carcinoma (OSCC) is increasing, with current estimates of age-standardized incidence and mortality of 6.6/100,000 and 3.1/100,000 in men and 2.9/100,000 and 1.4/100,000 in women, respectively. Mughees M, Sengupta A, Khowal S, Wajid S. Mol Biol Rep. 2021 Feb;48(2):1773-1786. doi: 10.1007/s11033-020-06054-6. Important risk factors related to the carcinoma itself that are associated with a poor prognosis include large size of the tumour at the time of diagnosis, the presence of metastases in regional lymphnodes, and a deep invasive front of the tumour. Highly differentiated carcinomas (n=26) had a survival probability of 78.9% and G2 and G3 tumors of only 48.9% (n=73, chi(2) test P<0.001). of Iran. The aim of the study was to establish the clinical and prognostic significance of PD-L1 in OSCC. 2018 May;47(5):443-453. doi: 10.1111/jop.12623. Deuerling L, Gaida K, Neumann H, Remmerbach TW. Would you like email updates of new search results? Epub 2017 Feb 16. 1 Cecelia E. Schmalbach, M.D., M.S. The five-year survival rate of OSCC patients has been reported approximately 50%, which is not satisfactory despite new treatment modalities. Tumor budding is an independent prognostic factor for prediction of lymph node metastasis in oral squamous cell carcinoma. Head and neck cancer, including oral squamous cell carcinoma (OSCC), is the sixth leading malignancy worldwide. Accessibility -. Conclusion. 2016 Feb;142(2):505-20. doi: 10.1007/s00432-015-2058-3. Bethesda, MD 20894, Copyright Oral squamous cell carcinoma (OSCC) is a major type of head and neck cancer, accounting for ~2%–4% of all incident cancer cases per year. Clinicopathological prognostic factors of oral squamous cell carcinoma: An experience of a tertiary care hospital 1117 Figure-1: (A) Kaplan-Meier curve for overall survival. Oral squamous cell carcinoma (OSCC) represents 95% of all forms of head and neck cancers. Despite improvements in diagnosis and patient management, survival and prognostic factors of patients with oral squamous cell carcinoma (OSCC) remains largely unknown in most of Sub Saharan Africa. Prospective and retrospective cohort studies were included to evaluate prognostic factors related to OSCC, such as etiologic factors, gender, location of the primary tumor, clinical tumor-node-metastasis (TNM) stage, histologic grade of malignancy, treatment, locoregional recurrence, and disease-specific survival rate. (Report) by "Journal of Pakistan Medical Association"; Health, general Cancer Chemotherapy Research Cancer metastasis Care and treatment Prognosis Cancer research Metastasis Oncology, Experimental Radiotherapy Squamous cell carcinoma 4.2. Recent studies confirm that oral cancer forms a large part of the cancer load in parts of India. Prevention and treatment information (HHS). Treated were 72 men and 27 women (average age 59 years) due to oral squamous cell carcinoma. Targeting Aurora B kinase with Tanshinone IIA suppresses tumor growth and overcomes radioresistance. 1993 Oct 1;53(19):4477-80 The aim of the present study was to analyze different prognostic factors to calculate the overall survival in oral squamous cell carcinoma (OSCC). This study emphasizes the importance of early diagnosis and aggressive treatment of oral squamous cell carcinoma. 2021 Jan;33(114):23-29. doi: 10.22038/ijorl.2020.44283.2463. Receiver Operating Characteristic (ROC) and area under curve (AUC) were used to evaluate and compare the prognostic value of immune cells. NCI CPTC Antibody Characterization Program. Bethesda, MD 20894, Copyright Objectives: To investigate the prognostic significance of preoperative neutrophil to lymphocyte ratio (NLR) and the impact of different clinical-pathologic factors in a series of primary oral squamous cell carcinomas (OSCC).Materials and Methods: All naive OSCCs treated with upfront surgery between 2000 and 2014 were retrospectively reviewed. Careers. 8600 Rockville Pike Oral squamous cell carcinoma affects mainly patients between the fifth and sixth decades of life, being rare in the young (≤40 years old). All tests were two-sided and p < 0.05 was considered statistically significant. However, in other solid tumors, grade is known to affect prognosis. Host, tumor, and treatment factors all have an important impact upon an individual patient's prognosis with laryngeal squamous cell carcinoma, whereas current staging systems only take into account tumor factors. Positive lymph node ratio is an important prognostic factor of oral squamous cell carcinoma. We conducted a retrospective cohort study … Clipboard, Search History, and several other advanced features are temporarily unavailable. In contrast to numerous clinicopathological parameters, the prognostic value of keratinization in oral squamous cell carcinoma (OSCC) is rarely reported in literature. We test the hypothesis that histologic grade is … Epub 2021 Jan 25. 2021 Feb 1;22(2):149-163. doi: 10.1080/15384047.2021.1877864. 1 Quintin Pan, Ph.D. 5 Samir Hanash, M.D., Ph.D. 6 J Craniomaxillofac Surg. Unable to load your collection due to an error, Unable to load your delegates due to an error. Among well-known molecular markers, cyclin dependent kinase, survivin, CD44, BUBR1, and heat shock proteins (27,70) can be considered as independent prognostic factors of survival rate. 2005 Jun 28;224(2):253-61. doi: 10.1016/j.canlet.2005.01.009. 2008 Feb;44(2):116-23 4 Douglas B. Chepeha, M.D., M.S.P.H. Biomarkers in diagnosis and therapy of oral squamous cell carcinoma: A review of the literature. To establish survival and associated factors among patients with oral squamous cell carcinoma treated at Mulago Hospital Complex, Kampala. 2006 Feb;42(2):208-17 Epub 2015 Jan 5. COVID-19 is an emerging, rapidly evolving situation. National Library of Medicine Please enable it to take advantage of the complete set of features! logical tolerance of solid tumors including oral squamous cell carcinoma (OSCC). Unable to load your collection due to an error, Unable to load your delegates due to an error. 3 Celina Kleer, M.D. There is a possibility of local or regional metastasis, which can involve the lymph nodes. Oral squamous cell carcinoma: Etiology, pathogenesis and prognostic value of genomic alterations Mehrotra R, Yadav S ... Risk factors for oral cancer The risk factors include tobacco associated intra-oral carcinogens, which may play a synergistic role in oral tumorigenesis. Cancers (Basel). Blatt S, Krüger M, Ziebart T, Sagheb K, Schiegnitz E, Goetze E, Al-Nawas B, Pabst AM. Int J Surg Pathol. Kaplan-Meier curves showing significant reduction is overall survival with (B) Lymph node involvement (C) …

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